普健生物（武汉）科技有限公司（AtaGenix）
Recombinant 2019-nCoV S -trimer Protein
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- 产品信息（Product Details）
- 如何订购
- 说明书
产品概述（Summary）icon
产品名称（Product name）
Recombinant2019-nCoV S -trimer Protein
货号（Catalog#）
ATMP02492COV
描述（description）
Recombinant SARS-CoV-2 S protein is produced by Mammalian cells expression system and the target gene encoding Met1-Gln1208 is expressed with C-His Tag
表达系统（Expression system）
Mammalian cells
种属（Species）
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Accession #
P0DTC2
别名（Alternative names)
Spike glycoprotein, S glycoprotein, E2, Peplomer protein
预测分子量（Predicted Molecular Mass）
138.09kDa
纯度（Purity）
>90% as determined by SDS-PAGE
内毒素（Endotoxin level）
Please contact with the lab for this information
制剂（Formulation）
Lyophilized.Lyophilized from a solution in PBS pH 7.4,1mM EDTA, 4% Trehalose, 1% Mannitol.
运输方式（Shipping）
In general, proteins are shipped out with blue ice unless customers require otherwise.
稳定性&储存（Stability &Storage）
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
复溶（Reconstitution）
Reconstitute in sterile water for a stock solution.
应用（Application）
Immunogen
电泳图（SDS-PAGE image）icon
活性（Bioactivity）icon
背景（Background）icon
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Noteicon
For research use only .
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