普健生物（武汉）科技有限公司（AtaGenix）
Recombinant Human IL2RA protein ,C- His Tag
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- 产品信息
- 前沿进展（Frontier progress）
- 如何订购
- 说明书
概述（Summary）icon
英文全称
Recombinant Human IL2RA protein ,C- His Tag
纯度（Purity）
>90% as determined by SDS-PAGE
内毒素（Endotoxin level）
< 1.0 EU per μg of the protein as determined by the LAL method.
蛋白构建（Construction）
A DNA sequence encoding the human IL2RA(Met1-Gln240) was fused with the C-terminal His Tag
Accession #
P01589
表达宿主（Host）
Mammalian cells
种属（Species）
Homo sapiens (Human)
预测分子量（Predicted Molecular Mass）
26.62kDa
制剂（Formulation）
Supplied as solution form in PBS or lyophilized from PBS .
运输方式（Shipping）
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性&储存（Stability &Storage）
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
复溶（Reconstitution）
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
电泳图（SDS-PAGE image）icon
活性（Bioactivity）icon
背景（Background）icon
背景介绍
Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
分子别名（Alternative Names）
IL2RA,CD25,p55,IL2-RA,IL-2-RA
参考文献（References）
Li, Ran, Xu, Luo, Song, Xu, Zhang (2020) Role of CD25 expression on prognosis of acute myeloid leukemia: A literature review and meta-analysis PloS one 15(7) e0236124
The gene expression for interleukin-2 receptor subunit alpha (CD25/IL2RA) is frequently altered in adults with acute myeloid leukemia (AML). Increasing evidence indicates that the elevated expression of CD25 may be correlated with poor survival for AML patients. Thus, we performed this meta-analysis to further evaluate the prognostic value of elevated CD25 in AML. Eligible studies were gathered by searching on PubMed, Web of Science, and Embase. Using the R language 3.6.0 software, Pooled hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) of overall survival (OS) and disease-free survival (DFS)/relapse-free survival (RFS)/event-free survival (EFS) for total and subgroup analyses were calculated to investigate the association of elevated CD25 and outcomes of AML patients. Ten studies with a total of 1640 participants were enrolled in this meta-analysis. Pooled HRs suggested that overexpression of CD25 predicted poor outcomes on both OS (HR = 2.27, 95%CI 1.95-2.64) and DFS/RFS/EFS (HR = 1.77, 95%CI 1.44-2.17) in overall population. Subgroup analyses stratified by ethnicity, AML subtype, cut-off value, statistical methodologies and detection method draw similar results. Our meta-analysis indicates that elevated CD25 expression is a poor prognostic factor for AML patients. Considering limited number of samples, further relevant studies are warranted.
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