普健生物(武汉)科技有限公司(AtaGenix)

Anti SREBP1 polyclonal antibody

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ATP177
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产品名(Product Name)icon
Anti SREBP1 polyclonal antibody
货号(Catalog No.)icon
ATP177
种类(Category)icon
Primary antibody
宿主(Host)icon
Rabbit
反应种属(Species specificity)icon
Human,other species was not test
应用实验(Tested applications)icon
ICC:1:50~200,IHC:1:50~100
克隆性(Clonality)icon
Polyclonal
偶连物(Conjugation)icon
Unconjugated
免疫原(Immunogen)icon
Recombinant protein of human SREBP1(Glu30-Leu490).
别名icon
SREBP-1,Sterol regulatory element-binding protein 1,BHLHD1,SREBP1,bHLHd1,Class D basic helix-loop-helix protein 1,SREBF1,Sterol regulatory element-binding transcription factor 1
Uniprot IDicon
P36956
状态(Form)icon
Liquid
储存溶液(Buffer)icon
PBS,pH7.4,containing 0.05% proclin300,50% glycerol.
存放条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4°C for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.
浓度(Concentration)icon
0.29mg/ml
亚型(Isotype)icon
IgG
分子量(MW)icon
54/126kDa
纯化方式(Purity)icon
Antigen affinity purification
ICC,IHC
    PMID: 8402897,PMID: 12177166,PMID: 32322062
    SREBF1, also named as BHLHD1 and SREBP1, contains one basic helix-loop-helix (bHLH) domain and belongs to the SREBP family. It is a transcriptional activator required for lipid homeostasis. The SREBPs are synthesized as precursors anchored to endoplasmic reticulum (ER) membranes and complexed with SCAP. When the cellular cholesterol level is low, SREBP-SCAP complexes move to the Golgi apparatus, where SREBPs undergo a two-step proteolytic processing, leading to the release of the mature form, an N-terminal fragment, i.e, basic helix-loop-helix leucine zipper transcription factor. These factors enter the nucleus where they bind to sterol regulatory elements (SRE) in the promoter regions of a number of genes whose products mediate the synthesis of cholesterol and fatty acids. [PMID: 21698267]. This antibody can recognize the 125kd precursor form and the 68kd mature form of human SREBF1.

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