Anti NFkB1 polyclonal antibody

Anti NFkB1 polyclonal antibody

ATP155

Primary antibody

Rabbit

Human,other species was not test

WB:1:2000~1:8000,ICC:1:50~200,IHC:1:50~100

Polyclonal

Unconjugated

Recombinant protein of human NFkB1(Met248-Ile366).

Nuclear factor NF-kappa-B p105 subunit,DNA-binding factor KBF1,EBP-1,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,NFKB1,DNA binding factor KBF1,EBP 1,KBF1,NF kappa B,NFKB p105,NFKB p50,NFKB1,NFKB1,p105,NFKB1,p105,p50,nfkb1a,p105,p50

P19838

Liquid

PBS,pH7.4,containing 0.05% proclin300,50% glycerol.

Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4°C for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.

0.75mg/ml

IgG

105kDa

Antigen affinity purification

WB,ICC,IHC

PMID: 15485931;PMID: 8710491;PMID: 11466314

NFkB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB is activated by various intra- and extracellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and bacterial or viral products. NFkB is a family of transcription factors that consists of homo- and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL1 alpha and TNF alpha as mediated by IkB kinase and p38 MAPK. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. This antibody can bind p105 isoforms of NFKB1.

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