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Anti RANKL polyclonal antibody

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产品名（Product Name）icon
Anti RANKL polyclonal antibody
货号（Catalog No.）icon
ATP116
种类（Category）icon
Primary antibody
宿主（Host）icon
Rabbit
反应种属（Species specificity）icon
Human,other species was not test
应用实验（Tested applications）icon
WB:1:2000~1:8000,ICC:1:50~200,IHC:1:50~100
克隆性（Clonality）icon
Polyclonal
偶连物（Conjugation）icon
Unconjugated
免疫原（Immunogen）icon
Recombinant protein of human RANKL(Tyr69-Asp317).
别名icon
Tumor necrosis factor ligand superfamily member 11,Osteoclast differentiation factor,ODF,Osteoprotegerin ligand,OPGL,Receptor activator of nuclear factor kappa-B ligand,RANKL,TNF-related activation-induced cytokine,TRANCE,CD254,TNFSF11,OPGL,RANKL,TRANCE
Uniprot IDicon
O14788
状态（Form）icon
Liquid
储存溶液（Buffer）icon
PBS,pH7.4,containing 0.05% proclin300,50% glycerol.
存放条件（Storage）icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4°C for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.
浓度（Concentration）icon
0.5mg/ml
亚型（Isotype）icon
IgG
分子量（MW）icon
35kDa
纯化方式（Purity）icon
Antigen affinity purification
WB,ICC,IHC
    PubMed:22664871;PMID: 17288531 ;PMID: 16828054
    TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL is a polypeptide of 217 amino acids that exerts its biological activity both in a transmembrane form of about 40-45 kDa and in soluble one of 31 kDa (PMID: 15308315). The membrane-bound RANKL (mRANKL) is cleaved into a sRANKL by the metalloprotease-disintegrin TNF-alpha convertase (TACE) or a related metalloprotease (MP). RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.

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    名称：Recombinant Mouse RANK L/TNFSF11 protein ,C- His Tag

    类别：其他蛋白

    货号：ATMP01820MO

    名称：Recombinant Mouse RANK L/TNFSF11 protein ,C- His Tag

    类别：其他蛋白

    货号：ATMP01821MO

    名称：Recombinant Human RANK L/TRANCE/TNFSF11 protein ,N- His Tag

    类别：其他蛋白

    货号：ATEP01822HU

    名称：Recombinant Human TNFSF11 protein , N- Fc Tag

    类别：其他蛋白

    货号：ATMP02326HU

    名称：Recombinant Human RANKL protein

    类别：其他蛋白

    货号：ATAP00255
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