普健生物（武汉）科技有限公司（AtaGenix）
Anti PD1 mouse monoclonal antibody
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- 产品性能
- 应用
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- 产品背景
- 如何订购
- 说明书
产品名（Product Name）icon
Anti PD1 mouse monoclonal antibody
货号（Catalog No.）icon
ATMA10133Mo
种类（Category）icon
Primary antibody
宿主（Host）icon
Mouse
反应种属（Species specificity）icon
Homo sapiens (Human)
克隆性（Clonality）icon
Monoclonal
克隆编号（Clone No.）icon
3G1
偶连物（Conjugation）icon
Unconjugated
免疫原（Immunogen）icon
Recombinant protein of full length human PD1
别名icon
PDCD1,PD1,Programmed cell death protein 1,Protein PD-1,CD279
Uniprot IDicon
Q15116
状态（Form）icon
Liquid
储存溶液（Buffer）icon
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
存放条件（Storage）icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
浓度（Concentration）icon
0.5mg/ml
亚型（Isotype）icon
IgG1
分子量（MW）icon
32kDa
纯化方式（Purity）icon
Protein G purified from mice ascites
WB:1:1000-1:4000,optimal working dilutions must be determined by end user.
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE , which is larger than its predicted mass of 32 kDa (PMID: 8671665; 17640856; 17003438).
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