普健生物(武汉)科技有限公司(AtaGenix)

Anti IGFBP1 mouse monoclonal antibody

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ATMA10116Mo
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产品名(Product Name)icon
Anti IGFBP1 mouse monoclonal antibody
货号(Catalog No.)icon
ATMA10116Mo
种类(Category)icon
Primary antibody
宿主(Host)icon
Mouse
反应种属(Species specificity)icon
Homo sapiens (Human)
克隆性(Clonality)icon
Monoclonal
克隆编号(Clone No.)icon
29-A8-G1
偶连物(Conjugation)icon
Unconjugated
免疫原(Immunogen)icon
Recombinant protein of full length human IGFBP1
别名icon
Insulin-like growth factor-binding protein 1,IBP-1,IGF-binding protein 1,IGFBP-1,Placental protein 12
Uniprot IDicon
P08833
状态(Form)icon
Liquid
储存溶液(Buffer)icon
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
存放条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
浓度(Concentration)icon
0.5mg/ml
亚型(Isotype)icon
IgG1
分子量(MW)icon
28kDa
纯化方式(Purity)icon
Protein G purified from mice ascites
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Insulin-like growth factor (IGF)-binding proteins (IGFBPs) family contains members like IGFBP-1, -2, -3, -4,-5 and-6. IGFBPs prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, but the effect of IGFBP-1 on cell migration may be independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin. Transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome.

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