普健生物（武汉）科技有限公司（AtaGenix）
Anti PDL1 mouse monoclonal antibody
- 1
- 产品概述
- 产品性能
- 应用
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- 如何订购
- 说明书
产品名（Product Name）icon
Anti PDL1 mouse monoclonal antibody
货号（Catalog No.）icon
ATMA10102Mo
种类（Category）icon
Primary antibody
宿主（Host）icon
Mouse
反应种属（Species specificity）icon
Homo sapiens (Human)
克隆性（Clonality）icon
Monoclonal
克隆编号（Clone No.）icon
18H5
偶连物（Conjugation）icon
Unconjugated
免疫原（Immunogen）icon
Plasmid of full length human PDL1
别名icon
B7 homolog 1,B7-H,B7-H1,B7H1,PD-L1,PDL1,CD274
Uniprot IDicon
Q9NZQ7
状态（Form）icon
Liquid
储存溶液（Buffer）icon
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
存放条件（Storage）icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
浓度（Concentration）icon
0.5mg/ml
亚型（Isotype）icon
IgG2b
分子量（MW）icon
33kDa
纯化方式（Purity）icon
Protein G purified from mice ascites
FACS:1:100-1:200
Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, it is predicted to be 27-30 kDa after signal peptide cleavage (PMID: 25609200; 17076679). The apparent molecular weight has also been reported as 45-70 kDa, major glycosylated form of 45-50 kDa and multiple post-translational modifications form of 65-70 kDa (PMID: 18760278; 16493058).
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