普健生物(武汉)科技有限公司(AtaGenix)

Anti PDL1 mouse monoclonal antibody

  • 1
ATMA10056Mo
-
+
现货
加入购物车
收藏
  • 产品概述
  • 产品性能
  • 应用
  • 参考文献
  • 产品背景
  • 如何订购
  • 说明书
产品名(Product Name)icon
Anti PDL1 mouse monoclonal antibody
货号(Catalog No.)icon
ATMA10056Mo
种类(Category)icon
Primary antibody
宿主(Host)icon
Mouse
反应种属(Species specificity)icon
Homo sapiens (Human)
应用实验(Tested applications)icon
Elisa,WB,flow,IHC
克隆性(Clonality)icon
Monoclonal
克隆编号(Clone No.)icon
130-A-5
偶连物(Conjugation)icon
Unconjugate
免疫原(Immunogen)icon
humna PDL1 DNA sequence
别名icon
B7-H1; CD274;Programmed death ligand 1
Uniprot IDicon
Q9NZQ7
状态(Form)icon
Liquid
储存溶液(Buffer)icon
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
存放条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
浓度(Concentration)icon
1mg/ml
亚型(Isotype)icon
IgG1
分子量(MW)icon
34 kDa
纯化方式(Purity)icon
Protein G purified from mice ascites
Elisa:1:1000~5000;WB:1:1000~4000;Flow:1:100~200,IHC:1:50~100
PMID: 10581077,PMID: 11015443,PMID: 28813417,PMID: 28813410,PMID: 28813417,PMID: 28813410
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.

1搜索商品:关键字搜索;分类导航搜索;产品联系:手机/微信同号:15972188750,座机:027-65279366(推荐 !

2产品选购:确定好产品信息与规格,向产品客服询问底价

3提交订单:向客服提交收货人信息,选择送货方式,支付方式,发票信息

4产品发货:发票随产品一起发送,耐心等待收货即可


质量保证:

所售产品均经过严格的质量检验,确保所供产品的技术指标与生产厂家的目录、说明书、质检报告上的描述一致,请放心选购。


质量与免责说明:

买方验收产品时,如发现产品短缺、不匹配、包装破损等情况,请保持产品原包装状态,并在收货七个工作日内,以书面方式向我司提出异议。逾期未提出异议视为合格。

买方保管产品时,应按照产品标签、说明书所示保管条件保存,如系保管不当导致产品质量问题,恕不受理。

买方使用产品时。如发现产品质量问题,应在使用初期提出,而非在使用完或快使用完时提出,以备我司回收产品,确认产品质量。如确属质量问题,我司负责调换或退货。发生索赔事宜,我司将在产品价格额度范围内酌情赔偿,恕不受理超出产品本身价值之部分。自收货之日起,超过三个月未反映产品问题,恕不退换。

我司所提供的产品仅限于专业人士的科学研究使用,不得用于临床诊断或者治疗,若有单位或者个人擅自改变我司产品用途,我司不承担任何责任。