Anti Her2 mouse monoclonal antibody

Anti Her2 mouse monoclonal antibody

ATMA10013Mo

Primary antibody

Mouse

Homo sapiens,other species was not test

IHC

Monoclonal

82-A-5

Unconjugate

Recombinant protein of full length human ErbB 2

Receptor tyrosine-protein kinase erbB-2;ERBB2;Metastatic lymph node gene 19 protein;Proto-oncogene Neu; CD340;HER2, MLN19, NEU, NGL

P04626

Liquid

PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.

1mg/ml

IgG1

138 kDa

Protein G purified from mice ascites

IHC:1:100~200

PMID: 10358079,PMID: 15380516,PMID: 21555369,PMID: 18719096,PMID: 21454582

Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu.
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

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