普健生物（武汉）科技有限公司（AtaGenix）
CD33 rabbit Polyclonal Antibody
- 1
- 产品概述
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- 应用
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产品名（Product Name）icon
CD33 rabbit Polyclonal Antibody
货号（Catalog No.）icon
ATA26325
种类（Category）icon
Primary antibodies
宿主（Host）icon
Rabbit
反应种属（Species specificity）icon
Human
应用实验（Tested applications）icon
WB,ELISA
克隆性（Clonality）icon
Polyclonal
偶连物（Conjugation）icon
Unconjugated
免疫原（Immunogen）icon
The antiserum was produced against synthesized peptide derived from the Internal region of human CD33. AA range:71-120
状态（Form）icon
Liquid
存放条件（Storage）icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 4 °C for frequent use.
Store at -20 to -80 °C for twelve months from the date of receipt.
纯化方式（Purity）icon
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).,online information:Siglec-3,PTM:Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.,tissue specificity:Monocytic/myeloid lineage cells.,
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